Teratogenicity/Fetotoxicity of DEHP in Mice
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منابع مشابه
Teratogenicity/fetotoxicity of DEHP in mice.
The embryonic/fetotoxic effects of DEHP on pregnant mice (ddY-Slc female x CBA male) were studied. DEHP was administered orally in dosages of 0.05 ml/kg to 30.0 mg/kg on day 6, 7, 8, 9 or 10 of gestation. A single administration of DEHP over 0.1 ml/kg (1/300 of LD50) on day 7 of gestation decreased the numbers and the body weight of living fetuses, whereas no significant changes in the numbers ...
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Due to its prevalence and known endocrine-disrupting properties, DEHP [di(2-ethylhexyl) phthalate] has been subject to extensive research into potential human health effects, especially related to the reproductive system.34 An article in Environmental Health Perspectives reports evidence that even small doses of DEHP may alter the courtship behavior of otherwise healthy adult male mice by reduc...
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A content of resin monomers and degradation prod-ucts[abstract]. EB, Lee-Chou L. In vitro elution of leachable components from dental sealants. The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo. Profound effects of the weak environmental estrogen-like chemical bisphe-nol A on the growth of the mammary gland of Noble rats. Interference with microtubules and...
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A content of resin monomers and degradation prod-ucts[abstract]. EB, Lee-Chou L. In vitro elution of leachable components from dental sealants. The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo. Profound effects of the weak environmental estrogen-like chemical bisphe-nol A on the growth of the mammary gland of Noble rats. Interference with microtubules and...
متن کاملTeratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice.
Di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) were mixed with diet at graded levels of 0.05, 0.1, 0.2. 0.4 and 1.0 wt-% and given to pregnant ICR mice throughout gestation. Maternal weight gain was suppressed and fetal resorption increased at 0.2, 0.4 and 1.0% levels of DEHP and 1.0% level of DBP. All the implanted ova died early in rats fed 0.4 and 1.0% levels of DEHP. Exter...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1982
ISSN: 0091-6765
DOI: 10.2307/3429386